Neurotrophin-3 mRNA a putative target of miR21 following status epilepticus
نویسندگان
چکیده
منابع مشابه
Blockade of p75 Neurotrophin Receptor Reverses Irritability and Anxiety-Related Behaviors in a Rat Model of Status Epilepticus
Background: Many recent epidemiological studies have shown that epileptic patients are more likely suffer from depression, anxiety, and irritability. However, the cellular mechanisms of epilepsy-induced psychotic behaviors are not fully elucidated. Neurotrophin receptors have been suggested to be involved in epilepsy and also in psychiatric disorders. Up-regulation of p75NTR expression and acti...
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Status epilepticus (SE) induces rapid hyper-activation of the hypothalamo-pituitary-adrenocortical (HPA) axis. HPA axis hyperactivity results in excess exposure to high levels of circulating glucocorticoids, which are associated with neurotoxicity and depression-like behavior. These observations have led to the hypothesis that HPA axis dysfunction may exacerbate SE-induced brain injury. To test...
متن کاملSpecific Subtypes of Cutaneous Mechanoreceptors Require Neurotrophin-3 Following Peripheral Target Innervation
Neurotrophin-3 (NT-3) is required for the development of most sensory neurons of the dorsal root ganglia. Using electrophysiological techniques in mice with null mutations of the NT-3 gene, we show that two functionally specific subsets of cutaneous afferents differentially require this factor: D-hair receptors and slowly adapting mechanoreceptors; other cutaneous receptors were unaffected. Mer...
متن کاملStatus epilepticus and refractory status epilepticus management.
Status epilepticus (SE) describes persistent or recurring seizures without a return to baseline mental status and is a common neurologic emergency. SE can occur in the context of epilepsy or may be symptomatic of a wide range of underlying etiologies. The clinician's aim is to rapidly institute care that simultaneously stabilizes the patient medically, identifies and manages any precipitant con...
متن کاملstatus epilepticus: a review
objective status epilepticus (se) has been described as a series of major motor seizure without recovery of consciousness between seizures. se is a medical emergency that requires prompt diagnosis and appropriate treatment. in this article we shall conclude history, epidemiology, etiology, risk factors, the best management as well as the prognosis of the condition.
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ژورنال
عنوان ژورنال: Brain Research
سال: 2011
ISSN: 0006-8993
DOI: 10.1016/j.brainres.2011.09.039